Their biggest problem may be posed by the pitch at Wembley with a NFL Super Bowl rematch between Philadelphia Eagles and Jacksonville Jaguars played in wet conditions just 24 hours before this game.
With that in mind, here are five bets to consider on tonight’s match.
City too classy
Whichever combination of players Pep Guardiola selects in midfield and attack, they look too have far too much strength for their opponents. A Manchester City win at a general 8/11 is too good to ignore.
Goals at a premium
Given the attacking talent on show in both teams, most punters will expect the net to bulge on a number of occasions. However, Manchester City have conceded just one goal on the road this season, with Tottenham conceding just three in three games at Wembley. Under 2.5 goals might just provide a touch of value at 13/10
Sterling effort
Raheem Sterling looks to have taken his game to another level this season and his record of a goal every three games in the Premier League for Manchester City – 35 goals in 104 appearances – means he should always be considered in goalscoring markets. He has already found the net in four games this season. He is available at 13/2 to score first and 7/4 to find the net at any time.