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It was a bad night for 10-man Arsenal at BATE Borisov on Thursday as the Gunners fell 1-0 in the first leg of a UEFA Europa League round of 32 tie.
A frustrated Alexandre Lacazette got a red card in the closing stages as the Premier League giants searched for an equaliser.
These teams first leg of round of 32
Chelsea faced a battle against Malmo, with the Swedish side backed by a noisy home crowd, but the Blues won 2-1.
Sevilla earned a 1-0 victory against Lazio in Italy, while Benfica completed a 2-1 win at Galatasaray.
Elsewhere, Valencia will take a 2-0 lead back to Spain after beating Celtic, and Villarreal overcame Sporting CP 1-0 in Portugal.
Napoli remain one of the tournament favourites after defeating FC Zurich 3-1 in their first leg.
Thursday’s First-Leg Results
BATE Borisov 1-0 Arsenal
Krasnodar 0-0 Bayer Leverkusen
Galatasaray 1-2 Benfica
Lazio 0-1 Sevilla
Olympiakos 2-2 Dynamo Kiev
Rapid Vienna 0-1 Inter Milan
Rennes 3-3 Real Betis
Slavia Prague 0-0 Genk
Celtic 0-2 Valencia
Club Brugge 2-1 Red Bull Salzburg
Zurich 1-3 Napoli
Malmo 2-1 Chelsea
Viktoria Plzen 2-1 Dinamo Zagreb
Shakhtar Donetsk 2-2 Eintracht Frankfurt
Sporting 0-1 Villarreal
Latest Odds To Win Europa League second leg of round of 32.
Chelsea: 4-1
Napoli: 6-1
Arsenal: 6-1
Inter: 10-1
Sevilla: 12-1
Valencia 20-1
Arsenal face an uphill task in the second leg and will play the February 21 match without Lacazette, who will be suspended.
The Frenchman was given his marching orders for an elbow in the closing stages, weakening the Gunners’ last stand.
Stanislav Dragun scored the only goal of the game for the Belarusian champions, heading home on the stroke of half-time.
The hosts were impressive as they resisted the English attack. Lacazette thought he had scored after the interval, but the effort was disallowed for offside.
Chelsea gave a rounded display on the road at Malmo but suffered scares along the way.Lars Dareberg/Getty Images
Ross Barkley’s goal after 30 minutes established a lead for the Blues, and Olivier Giroud finished with a back heel to make it 2-0 shortly before the hour mark.
Anders Christiansen kept the tie alive for Malmo, scoring with 10 minutes remaining to give the Swedes hope.
Sevilla grabbed a one-goal advantage from their trip to Rome, defeating Lazio with a first-half strike from Wissam Ben Yedder.
Inter grabbed a precious 1-0 lead as Lautaro Martinez converted a penalty shortly before half-time.
In other games, Benfica will be the favourites to progress from their tie, winning 2-1 away in Istanbul.
Eduardo Salvio’s spot-kick gave the visitors the breakthrough after 27 minutes, but Christian Luyindama equalised in the second half.
Haris Seferovic scored the winner for the Portuguese giants, finding the top corner after the hour mark.
It was a bad night for Scottish champions Celtic, beaten 2-0 at home by Valencia.
Goals either side of the interval settled the game on the night, with Denis Cheryshev and Ruben Sobrino netting for the La Liga side.
Villarreal capped off a strong night for La Liga teams as they defeated Sporting 1-0 with a third-minute strike from Alfonso Pedraza. Marcos Acuna will miss the second leg after seeing red for the Portuguese club.
Napoli will believe they will progress after a 3-1 win on the road against Zurich.
Lorenzo Insigne gave the Italians the perfect start after 11 minutes, and Jose Callejon doubled the advantage moments later.
Piotr Zielinski made it a three-goal lead in the second half, but a late penalty from Benjamin Kololli gave a crumb of comfort to the hosts