LONDON — Before returning to the top of the Premier League, Liverpool got to savor a Manchester United humiliation.

Now, unusually, Liverpool needs a swift recovery by its great rival after United’s despair in being routed 4-0 by Everton on Sunday.

Liverpool’s hopes of ending a 29-year English title drought could hinge on a big favor from sixth-place United when it hosts Manchester City on Wednesday.

After beating Cardiff 2-0 on Sunday, Liverpool is two points ahead of City with three games remaining. But Pep Guardiola’s champions have a game in hand over Liverpool so defending the title is still in their control — unless they fail to beat United.

For Arsenal, the challenge in its remaining four matches is sealing a top-four finish to qualify for the Champions League. That mission was hampered by a 3-2 home loss to Crystal Palace that left Unai Emery’s side only in fourth place, ahead of Chelsea on goal difference and a point behind Tottenham.